STAT2 phosphorylation and signaling.
- Resource Type
- Article
- Authors
- Steen, Håkan C; Gamero, M
- Source
- JAK-STAT. Oct-Dec2013, Vol. 2 Issue 4, pe25790-1-e25790-8. 8p.
- Subject
- *STAT proteins
*PHOSPHORYLATION
*INTERFERONS
*TRANSCRIPTION factors
*BIOCHEMISTRY
- Language
- ISSN
- 2162-3988
STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling. This review aims to summarize knowledge of phosphorylation-mediated STAT2-regulation and future avenues of related STAT2 research. [ABSTRACT FROM AUTHOR]