Lymphocyte calcium signaling from membrane to nucleus.
- Resource Type
- Article
- Authors
- Gallo, Elena M.; Canté-Barrett, Kirsten; Crabtree, Gerald R.
- Source
- Nature Immunology. Jan2006, Vol. 7 Issue 1, p25-32. 8p.
- Subject
- *LYMPHOCYTES
*B cells
*CALCIUM
*GENE expression
*IMMUNE response
*IMMUNOLOGY
- Language
- ISSN
- 1529-2908
Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function. [ABSTRACT FROM AUTHOR]