Episodes of demyelinating neuropathy and skin lesions have not recurred, isolated monocular abducens paralysis has improved, and pontine lesions have disappeared after eculizumab treatment (Fig. Keywords: congenital CD59 deficiency; relapsing demyelinating peripheral neuropathies; blistering skin lesions; reversible monocular abducens palsy EN congenital CD59 deficiency relapsing demyelinating peripheral neuropathies blistering skin lesions reversible monocular abducens palsy 140 142 3 04/21/22 20220301 NES 220301 Introduction Congenital CD59 deficiency is a recently described disease resulting from mutations in I CD59 i gene. In conclusion, congenital CD59 deficiency should be the first preliminary diagnosis that comes to mind in the diagnosis of a patient with recurrent Guillain-Barré syndrome-like attacks, concomitant blistering skin lesions, and reversible isolated cranial neuropathy episodes, especially triggered by infection. [Extracted from the article]