The article focuses on a study which determined the priorities of low-income women regarding health, relationships, and social concerns, focusing on the importance of addressing HIV and AIDS. Women's mean rating of 48 health and social concerns shows the percentage of participants who indicated that they would attend an educational or self-help program on this topic if it were offered. Women's interest in attending groups paralleled their interest in the topics with the largest percentages interested in social and relationship issues and lesser interest in mental and somatic health concerns. The percentage of women who were interested in attending educational or self-help groups was strongest for AIDS and greater than all categories and individual concerns. One of the few to assess directly the perceptions of low-income, primarily ethnic minority women regarding common health, interpersonal, and social threats, underscore the importance of addressing health problems, including HIV, in the context of other social problems. The findings also confirm that AIDS is now seen as a major health threat and that women welcome interventions to reduce their risk. Continued monitoring of women's concerns is advisable to enhance the sensitivity of health interventions and their likely reception in community-based sampIes.