Aquaporin-11 control of testicular fertility markers in Syrian hamsters.
- Resource Type
- Article
- Authors
- Shannonhouse, John L.; Urbanski, Henryk F.; Woo, Shih-Lung; Fong, Li An; Goddard, Scott D.; Lucas, William F.; Jones, Edward R.; Wu, Chaodong; Morgan, Caurnel
- Source
- Molecular & Cellular Endocrinology. Jun2014, Vol. 391 Issue 1/2, p1-9. 9p.
- Subject
- *AQUAPORINS
*TESTIS
*MAMMAL fertility
*GOLDEN hamster
*PHOTOPERIODISM
*GENETIC markers
*RODENTS
- Language
- ISSN
- 0303-7207
Highlights: [•] Differential display PCR revealed candidate genes for control of fertility in testis during photoperiodic modulation. [•] Multiple linear regression modeling helped identify aquaporin-11 as the best fit among the candidate genes. [•] RNA interference of Aqp11, using small interfering RNA demonstrated Aqp11 tonically induces markers of fertility. [•] The collective results provide the first molecular evidence that Aqp11 regulates fertility. [ABSTRACT FROM AUTHOR]