This article discusses familial comedonal Darier's disease (CDD), a rare variant of Darier's disease (DD), which is an autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene. CDD is characterized by prominent follicular involvement, resulting in the formation of large comedo-like lesions primarily on the face and scalp. The article presents a case study of a 45-year-old woman with familial CDD, along with her family members who had different subtypes of DD. The study identifies a new mutation in the ATP2A2 gene and emphasizes the importance of thorough exploration of relatives in diagnosing CDD due to its clinical variability. [Extracted from the article]