A report from the US National Academies of Sciences, Engineering, and Medicine emphasizes the importance of increasing representation of underrepresented populations in clinical trials and research. The lack of diversity in research leads to findings that cannot be widely applied, undermines trust in medical research, contributes to health disparities, and costs society billions of dollars. The report provides 17 recommendations to improve representation, including increasing research conducted in safety net health systems, such as Federally Qualified Health Centers (FQHCs), which serve diverse populations. Increasing research in FQHCs can address evidence gaps, leverage federal incentives, and improve health outcomes for diverse populations. [Extracted from the article]