Introduction: Spastic children are a group of home dependant or even bedridden patients related to the degree of their spasticity. They need home care and are in frequent risk of hospitalization and getting hospital care due to frequent infections. Materials and Methods: In this study, we retrospectively evaluated the seroprevalance of hepatitis A, B, and C in 400 children aged 1-18 years, with cerebral palsy and other neurological problems who were hospitalized at different times in Doctor Ayten Bozkaya Spastic Children's Hospital which is the only institution that is specialized on care of this group of patients. Children who were vaccinated against hepatitis A were not included. The patients were divided into two groups. Group 1 consisted of 82 children who were born before 1998 and were not vaccinated against hepatitis B. Group 2 consisted of 308 children born after 1998 and been vaccinated with three doses of hepatitis B. Results: Hepatitis A seroprevalance was 19% in total. According to age groups, seroprevalance of hepatitis A was 16% between 12-23 months, 12% between 2-5 years, 18% between 6-12 years, and 37% between 13-18 years. In group 1, chronic carrier state for hepatitis B was 1.2%, Anti-HBs IgG positivity was 8.5%, the ratio of those with HBs Ag negativity and Anti-HBc IgG positivity was 9.7%, and HBV sensibility (anti-HBs IgG and Anti-HBc IgG negative) was 80%. In group 2, the same frequencies were 0.3%, 79.5%, 2.2%, and 18% respectively. Anti HBs positivity was 11.6% in children born before 1998. Anti HCV was positive in only one child which was interpreted as false positivity, because HCV RNA resulted negative and HCV antibody was also found negative six months later. Conclusions: Low seroprevalance of hepatitis A was attributed to more protected and indoors life of these children. Low prevalance of hepatitis B and C in this group of patients might be due to the low frequency of blood transfusions and invasive procedures despite more frequent hospitalization. [ABSTRACT FROM AUTHOR]