Synthesis of imidazolinone and benzoxazole derivatives, and evaluation of their anticancer activity.
- Resource Type
- Article
- Authors
- El-Hady, Heba; Abubshait, Samar
- Source
- Research on Chemical Intermediates. Mar2015, Vol. 41 Issue 3, p1833-1841. 9p. 1 Diagram, 3 Charts, 4 Graphs.
- Subject
- *IMIDAZOLINONES
*BENZOXAZOLES
*OXAZOLES synthesis
*CHEMICAL derivatives
*ANTINEOPLASTIC agents
- Language
- ISSN
- 0922-6168
A series of imidazolinone and benzoxazole derivatives ( 3 and 5) have been synthesized by condensation of oxazolinone derivatives ( 2a-c) with aniline and 2-hydroxyaniline. Acetyl derivatives ( 4 and 6) were prepared by acetylation of compounds 3 and 5 with acetic anhydride. Reaction of compound 5 with chloroacetyl chloride produced chloroacetyl derivative 7. The results revealed that the imidazolinone and benzoxazole derivatives had potent activity against cancer cell lines MCF-7 and HePG2, and that the benzoxazole derivatives were more potent than imidazolinone derivatives. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]