Azadepsipeptides: Synthesis and Evaluation of a Novel Class of Peptidomimetics.
- Resource Type
- Article
- Authors
- Dyker, Hubert; Scherkenbeck, Jurgen; Gondol, Daniel; Goehert, Axel; Harder, Achim
- Source
- Journal of Organic Chemistry. 06/01/2001, Vol. 66 Issue 11, p3760. 7p. 4 Diagrams, 2 Charts.
- Subject
- *PEPTIDE synthesis
*NITROGEN
*ANALYTICAL chemistry
- Language
- ISSN
- 0022-3263
Examines the generation of azadepsipeptide structures, a novel class of peptidomimetics. Synthesis of a bis-aza analogue of the antiparasitic cyclooctadepsipeptide PF1022A; Comparison of the X-ray crystal structures of natural PF1022A and the chimeric aza analogue; Introduction of nitrogen in the backbone of PF1022A.