Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation.
- Resource Type
- Article
- Authors
- Evonuk, Kirsten S.; Doyle, Ryan E.; Moseley, Carson E.; Thornell, Ian M.; Adler, Keith; Bingaman, Amanda M.; Bevensee, Mark O.; Weaver, Casey T.; Min, Booki; DeSilva, Tara M.
- Source
- Science Advances. Jan2020, Vol. 6 Issue 2, p1-13. 13p.
- Subject
- *OLIGODENDROGLIA
*AMPA receptors
*GLYCINE receptors
*AXONS
*INFLAMMATION
*CENTRAL nervous system
- Language
- ISSN
- 2375-2548
The article presents a study on how reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Topics discussed include excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury; glutamate-stimulated calcium influx into oligodendrocyte somas is AMPA receptor; and mature oligodendrocytes to the pathophysiology of myelinated axons.