In the last 2 years, several studies investigated the immunological responses to SARS-CoV-2 infections and/or COVID-19 vaccinations,1-6 but long-term immunological effects in response to different vaccination combinations are poorly defined. In this regard, vaccination regimes including BNT162b2 elicit strong immune responses with a more rapid decline, whereas vector-based vaccinations yield lower and comparably stable immunological effects. For the groups with BNT162b2 as a second vaccination, anti-spike-RBD-IgG was negatively associated with the days elapsed since the second vaccination (Figure 1C, left panel) suggesting higher antibody dynamics for vaccination regimes including BNT162b2. [Extracted from the article]