Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies.
- Resource Type
- Case Study
- Authors
- Paranjpe, Madhav; Mann, Peter; Denton, Melissa
- Source
- Toxicologic Pathology. Feb2022, Vol. 50 Issue 2, p232-234. 3p.
- Subject
- *SQUAMOUS cell carcinoma
*PARANEOPLASTIC syndromes
*CARCINOGENICITY
- Language
- ISSN
- 0192-6233
Non-glandular squamous cell carcinoma (NGSCC) is an extremely rare tumor in Tg.raH2 mice. There have been 5 NGSCC in 1615 control male mice (0.31%) and 2 NGSCC in 1560 control female mice (0.13%) on 26-week carcinogenicity studies, with a range of 0 to 1 of per group per sex in each study without statistical significance in 52 male and 51 female studies conducted in Tg.rasH2 mice. Every case of NGSCC was accompanied by profound granulocytosis. [ABSTRACT FROM AUTHOR]