Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs.
- Resource Type
- Article
- Authors
- Vilar, Jose M; Damiá, Elena; Rubio, Mónica; Santana, Angelo; Sopena, Joaquin; Ceron, Joaquin; Tvarijonaviciute, Asta; Cugat, Ramón; Carrillo, Jose Maria
- Source
- Journal of Applied Animal Research. Dec2017, Vol. 45 Issue 1, p490-493. 4p.
- Subject
- *GROWTH factors
*CANCER
*INFLAMMATION
*SOMATOMEDIN
*C-reactive protein
*INTRAMUSCULAR injections
- Language
- ISSN
- 0971-2119
A potential relationship between an increased risk of cancer and increased levels of serum insulin-like growth factor-1 (IGF-1), and presence of cancer and high levels of C-reactive protein (CRP) has been previously reported. This study evaluated the influence of a single intramuscular injection of plasma rich in growth factors (PRGF) on serum concentrations of IGF-1 and CRP in dogs. Two groups of eight healthy beagles were injected with two different doses of PRGF in lumbar muscles. For each treatment, IGF-1 and CRP were analysed from blood samples obtained at baseline and the following three days post injection. No differences were found when IGF-1 and CRP were compared among times in the two protocols. Local application of PRGF at clinical doses did not cause significant changes in systemic concentrations of IGF-1 or detectable inflammation. [ABSTRACT FROM AUTHOR]