BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the effects of a 10-week core and mobility training program on pain perception and low back disability score in professors, students and employees of a university. METHODS: Twenty-four individuals of a university who previously reported pain and low back disability were randomly assigned to an experimental group (EG; n = 8) that received 2 weekly sessions of 50 minutes of core and mobility training for 10 weeks; or to a control group (CG; n = 16). Both groups received a guideline to adopt ergonomic postures during work and activities of daily living. The visual analog pain scale (VAS) and the Roland-Morris questionnaire (RMQ) were applied pre- and post intervention. RESULTS: Significant reductions in the pain intensity perception (p = 0.014) and low back functional disability (p = 0.011) were noted in the EG pre- and post measures. However, no significant difference was observed in the CG. Thus, there was a significant difference between the EG and the CG in the post-intervention measures (p = 0.001). CONCLUSION: Core and mobility training and home-ergonomic instructions were effective to reduce the pain intensity perception and low back functional disability in the EG. [ABSTRACT FROM AUTHOR]