In summary, Alzheimer’s can be viewed as the end result of a severe and/or long term functional imbalance between synaptoblastic and synaptoclastic influences in the brain. While beta amyloid serves as both a mediator and a marker of the pathology, and should be reduced, the most useful clinical targets are the upstream factors driving the beta amyloid production. These factors are many and varied between individuals, and can include inflammatory, cardiometabolic, hormonal, nutritional and toxic features. A successful treatment approach hinges upon the identification of each individual’s specific risk factors, with targeted, comprehensive treatment to optimise as many areas of functioning as possible. Such a treatment approach uses a lifestyle medicine foundation incorporating the elements of DESS – diet, exercise, sleep and stress reduction, as well as specific nutrition and herbal interventions to optimise patient-specific aspects of health. Such an approach has been at the core of Bredesen’s success with Alzheimer’s patients and provides a methodology to emulate for clinicians looking for success models in this difficult and important area of practice. [ABSTRACT FROM AUTHOR]