Mitochondrial dysfunction and drug targets in multiple myeloma.
- Resource Type
- Article
- Authors
- Cui, Yushan; Wang, Fujue; Fang, Baijun
- Source
- Journal of Cancer Research & Clinical Oncology. Aug2023, Vol. 149 Issue 10, p8007-8016. 10p.
- Subject
- *MULTIPLE myeloma
*DRUG target
*MITOCHONDRIA
*MITOCHONDRIAL DNA
*HEMATOLOGIC malignancies
*LEBER'S hereditary optic atrophy
*MITOCHONDRIAL pathology
- Language
- ISSN
- 0171-5216
Multiple myeloma (MM) is the second most common hematological cancer that has no cure. Although currently there are several novel drugs, most MM patients experience drug resistance and disease relapse. The results of previous studies suggest that aberrant mitochondrial function may contribute to tumor progression and drug resistance. Mitochondrial DNA mutations and metabolic reprogramming have been reported in MM patients. Several preclinical and clinical studies have shown encouraging results of mitochondria-targeting therapy in MM patients. In this review, we have summarized our current understanding of mitochondrial biology in MM. More importantly, we have reviewed mitochondrial targeting strategies in MM treatment. [ABSTRACT FROM AUTHOR]