This document is a response to concerns raised about the American College of Physicians' (ACP) guidance statement on screening for colorectal cancer (CRC) in asymptomatic average-risk adults. The authors address various criticisms and disagreements regarding the age at which screening should begin, the frequency of screening, and the use of stool tests in younger populations. They emphasize the importance of considering individual patients' values and preferences, as well as the benefits, risks, and costs associated with different screening strategies. The authors acknowledge the potential for confusion due to conflicting guidelines but stress the need to incorporate evidence limitations and diverse perspectives when making screening decisions. [Extracted from the article]