Flying under the radar: TMEM106B(120–254) fibrils break out in diverse neurodegenerative disorders.
- Resource Type
- Article
- Authors
- Copley, Katie E.; Shorter, James
- Source
- Cell. Apr2022, Vol. 185 Issue 8, p1290-1292. 3p.
- Subject
- *NEURODEGENERATION
*AMYLOID
- Language
- ISSN
- 0092-8674
Neurodegenerative diseases commonly exhibit aggregation of specific proteins that define each disease. Chang et al. (2022) establish that a C-terminal fragment of TMEM106B, a frontotemporal-lobar-degeneration risk factor, unexpectedly forms amyloid fibrils with similar structures in diverse neurodegenerative disorders. These unanticipated TMEM106B(120–254) fibrils may herald etiological shifts for several neurodegenerative diseases. [ABSTRACT FROM AUTHOR]