While topical corticosteroids are also often used for infantile psoriasis, the large surface area of moderate-to-severe GPP entails a higher risk for systemic side effects. It accounts for only 0.6%-13.1% of all childhood psoriasis.[[1], [3]] The loss-of-function mutation of interleukin-36 receptor antagonist (IL36Ra) has been associated with development of GPP.[4] Interestingly, IL-17 mRNA levels were also noted to be higher in pustular psoriasis in comparison with other clinical subtypes.[5] We reported a three-month-old Filipino girl born at term via caesarean section with otherwise unremarkable antenatal and birth history. Keywords: biologics; case report; infantile generalized pustular psoriasis; interleukin-17; secukinumab EN biologics case report infantile generalized pustular psoriasis interleukin-17 secukinumab 1296 1298 3 08/09/23 20230801 NES 230801 Generalized pustular psoriasis (GPP) is a rare form of psoriasis characterized by disseminated sterile pustules. [Extracted from the article]