EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications.
- Resource Type
- Article
- Authors
- Raia-Barjat, Tiphaine; Chauleur, Céline; Collet, Constance; Rancon, Florence; Hoffmann, Pascale; Desseux, Morgane; Lemaitre, Nicolas; Benharouga, Mohamed; Giraud, Antoine; Alfaidy, Nadia
- Source
- Scientific Reports. 11/14/2023, p1-6. 6p.
- Subject
- *PREMATURE labor
*PREGNANT women
*ASYMPTOMATIC patients
- Language
- ISSN
- 2045-2322
Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women. [ABSTRACT FROM AUTHOR]