Design and synthesis of 2'-deoxy-2'-fluorodisaccharides as mechanism-based glycosidase inhibitors...
- Resource Type
- Article
- Authors
- McCarter, John D.; Wai Yeung; Chow, Jack; Dolphin, David; Withers, Stephen G.
- Source
- Journal of the American Chemical Society. 06/25/97, Vol. 119 Issue 25, p5792. 6p. 2 Diagrams, 3 Graphs.
- Subject
- *DISACCHARIDES
*GLYCOSIDASE inhibitors
- Language
- ISSN
- 0002-7863
Examines the design and synthesis of 2'-deoxy-2'fluorodisaccharides as mechanism-based glycosidase inhibitors which exploit aglycon specificity. Potential in the study of oligosaccharides processing mechanisms; Description of the inactivation process; Sufficient transition state stabilization by interactions of enzymes and sugar aglycon.