Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.
- Resource Type
- Article
- Authors
- Chan, Ai-Ci; Shan, Pei-Ya; Wu, Men-Hsin; Lin, Pin-Han; Tsai, Chang-Shun; Hsu, Chia-Chien; Chiu, Ting-Hsiang; Hsu, Ting-Wei; Yeh, Yi-Cheun; Lai, Yun-Ju; Liu, Wei-Min; Tu, Ling-Hsien
- Source
- Chemical Communications. 9/14/2023, Vol. 59 Issue 71, p10660-10663. 4p.
- Subject
- *AMYLIN
*ANTI-infective agents
*STRUCTURE-activity relationships
- Language
- ISSN
- 1359-7345
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure–activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity. [ABSTRACT FROM AUTHOR]