A population-based LD map of the human chromosome 6p.
- Resource Type
- Article
- Authors
- Yu, Hong; Chia, Jer-Ming; Bourque, Guillaume; Wong, Marie; Chan, Soh; Ren, Ee
- Source
- Immunogenetics. Sep2005, Vol. 57 Issue 8, p559-565. 7p. 3 Diagrams, 2 Graphs.
- Subject
- *HUMAN chromosomes
*MAJOR histocompatibility complex
*GENETIC polymorphisms
*NUCLEOTIDE sequence
*GENE mapping
*POPULATION genetics
- Language
- ISSN
- 0093-7711
The recent publication of the complete sequence of human chromosome 6 provides a platform from which to investigate genomic sequence variation. We report here a detailed linkage disequilibrium (LD) pattern map across the entire human chromosome 6p by using a set of 1152 single nucleotide polymorphisms (SNPs) in a population of 198 Singaporean Chinese, with 326 SNPs focused in the major histocompatibility complex (MHC) region. Our analysis shows some unexpectedly high segments of strong LD in a 10-Mb region that includes the extremely polymorphic and gene-rich MHC loci and many non-MHC genes. These include the telomeric peri-MHC region that harbors olfactory receptors, histones and zinc finger clusters, and the centromeric peri-MHC region that contains several unknown open reading frames. The data also help refine a human–mouse synteny break in the region between 28.6 and 29.4 Mb. The population-based LD map presented here will provide an essential resource for understanding the genomic sequence variation of chromosome 6p and LD mapping of disease genes of complex genetic traits. [ABSTRACT FROM AUTHOR]