The choice of MTX in our patient was also guided by the recent diagnosis of rheumatoid arthritis, this therapy has in fact allowed to control both diseases with a single drug. Generalized eruptive keratoacanthoma (GEKA) is an extremely rare variant of multiple keratoacanthoma (KA) affecting the skin and mucous membranes, described for the first time by Grzybowski in 1950.1 So far, approximately 30 cases are reported worldwide.2 Middle-aged adults in the fifth to seventh decades of life are typically affected, without sex predilection, and most of the reported patients are white. [Extracted from the article]