Outcomes of haploidentical hematopoietic stem cell transplantation with 'Beijing protocol' in pediatric myeloid neoplasms post cytotoxic therapy: a case series study.
- Resource Type
- Article
- Authors
- Zhang, Feng; Hu, Guan-hua; Zhang, Le-ping; Xu, Lan-ping; Suo, Pan; Wang, Yu; Bai, Lu; Liu, Kai-yan; Zhang, Xiao-hui; Huang, Xiao-jun; Cheng, Yi-fei
- Source
- Leukemia & Lymphoma. Mar2024, Vol. 65 Issue 3, p383-388. 6p.
- Subject
- *HEMATOPOIETIC stem cell transplantation
*TUMORS
*STEM cell transplantation
*GRANULOCYTE-colony stimulating factor
- Language
- ISSN
- 1042-8194
This letter to the editor discusses the outcomes of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with the "Beijing protocol" in pediatric myeloid neoplasms post cytotoxic therapy (MN-pCT). MN-pCT is a rare complication in pediatric cancer survivors, and research on this population is limited. The study reports the outcomes of pediatric patients with MN-pCT who underwent haplo-HSCT, which is the only treatment providing long-term survival. The study found that haplo-HSCT using the Beijing protocol resulted in long-term survival with low treatment-related mortality. The authors suggest that haplo-HSCT may be a suitable alternative when matched sibling or unrelated donors are unavailable. [Extracted from the article]