P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.
- Resource Type
- Article
- Authors
- Zhou, Jun; Zhan, Songhua; Tan, Wenli; Cheng, Ruixin; Gong, Hangjun; Zhu, Qiong
- Source
- Biochemical & Biophysical Research Communications. Feb2014, Vol. 444 Issue 3, p387-390. 4p.
- Subject
- *COLON cancer
*HISTONE acetyltransferase
*GENETIC mutation
*ACETYLATION
*CANCER cell growth
*FIBROBLASTS
*PREVENTION
- Language
- ISSN
- 0006-291X
Highlights: [•] MTA2 is acetylated at K152. [•] Histone acetyltransferase p300 binds to and acetylates MTA2. [•] Mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells. [ABSTRACT FROM AUTHOR]