Copper‐Catalyzed Chemo‐ and Diastereoselective 1,3‐Dipolar Cycloaddition of Carbonyl Ylide and Aldehyde‐Tethered‐Cyclohexadienone to Access Polycyclic Systems.
- Resource Type
- Article
- Authors
- Peng, Shiyong; Zhang, Hong; Zhu, Yuqi; Zhou, Ting; He, Jieyin; Chen, Nuan; Lang, Ming; Li, Hongguang; Wang, Jian
- Source
- Advanced Synthesis & Catalysis. 10/5/2021, Vol. 363 Issue 19, p4532-4537. 6p.
- Subject
- *DIAZO compounds
*DIVERSIFICATION in industry
*RING formation (Chemistry)
*COPPER catalysts
- Language
- ISSN
- 1615-4150
A copper‐catalyzed tandem intermolecular ylide formation/intramolecular cycloaddition of diazo compounds and aldehyde‐tethered‐cyclohexadienones was reported, chemo‐ and diastereoselectively providing oxapolycyclic frameworks in moderate to excellent yields under mild conditions. This reaction creates two C−C bonds and one C−O bond with five stereocentres including two all‐carbon quaternary centres. Moreover, the late‐stage diversification of products can be realized via chemoselective substitutions. [ABSTRACT FROM AUTHOR]