Somatic mutational analysis of FAK in breast cancer: A novel gain-of-function mutation due to deletion of exon 33.
- Resource Type
- Article
- Authors
- Fang, Xu-Qian; Liu, Xiang-Fan; Yao, Ling; Chen, Chang-Qiang; Gu, Zhi-Dong; Ni, Pei-Hua; Zheng, Xin-Min; Fan, Qi-Shi
- Source
- Biochemical & Biophysical Research Communications. Jan2014, Vol. 443 Issue 2, p363-369. 7p.
- Subject
- *SOMATIC mutation
*FOCAL adhesion kinase
*GENETICS of breast cancer
*DELETION mutation
*EXONS (Genetics)
*CELL migration
- Language
- ISSN
- 0006-291X
Highlights: [•] A novel FAK splicing mutation identified in breast tumor. [•] FAK-Del33 mutation promotes cell migration and invasion. [•] FAK-Del33 mutation regulates FAK/Src signal pathway. [ABSTRACT FROM AUTHOR]