Background: Crimean-Congo hemorrhagic fever (CCHF) continues to pose a serious threat to the fragile healthcare system of Pakistan with a continuous increase of morbidity and mortality. The present study aimed to assess the knowledge, attitudes, and practices regarding CCHF among general people who resided in Pakistan. Methods: An online cross-sectional survey design was applied, and a convenience sampling technique was used to recruit 1039 adult people from Pakistan. Data were collected from September 08 to October 12, 2021. The questionnaire consisted of a total of 32 questions in four parts assessing socio-demographics, as well as knowledge, attitudes, and practices regarding CCHF. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS), and logistic regression analyses were performed to determine the factors associated with good knowledge, positive attitudes, and good practices. Results: Alarmingly, 51.5% of participants heard about CCHF infection before administering the survey. Among these, 20.2%, 33.3%, and 48.2% of the study participants had demonstrated good knowledge, positive attitudes, and good practices, respectively. Binary logistic regression analysis revealed that education and income status had a significant impact on knowledge and attitudes (p<0.05). Similarly, the mean attitude scores differed significantly by age, education, and income status (p<0.05). Conclusions: The findings reflected inadequate levels of knowledge, attitudes, and practices regarding CCHF among general people in Pakistan which may regard as lower than expected. As CCHF is a highly contagious disease, it's urgent to initiate a comprehensive approach to handle the situation before it spreads further in Pakistan. Author summary: Crimean-Congo hemorrhagic fever (CCHF) is usually transmitted by ticks or contact with viremic animal tissues (animal tissue where the virus has entered the bloodstream) during and immediately after post-slaughter of animals and can lead to epidemics, has a high case fatality ratio (10–40%), potentially results in hospital and health facility outbreaks, and is difficult to prevent and treat. The number of CCHF infections increases around Eid-ul-Adha as more livestock is moved from rural areas to cities during Eid-ul-Adha. In Pakistan, the current national control program has been unable to eliminate CCHF on its own. Therefore, sociocultural and behavioral research can inform and improve the impact of future control programs. To this end, we investigated knowledge, attitudes, and practices related to CCHF in general population of Pakistan. We alarmingly found low levels of disease knowledge and attitudes and practices. Preventive interventions are uncommon due to poor infrastructure, a lack of education, and restricted access to health care and livestock-related facilities. It is high time that Pakistan's health, agriculture, and media sectors collaborate with international organizations to establish and implement a strategic framework for CCHF awareness and prevention. This kind of social context is vital to future public health campaigns, and highlights the importance of cross-disciplinary work to achieve successful disease control. [ABSTRACT FROM AUTHOR]