Hand, foot, and mouth disease (HFMD) is an acute, self-limited, highly contagious viral illness that commonly affects children younger than 5 years and is characterized by lesions of the oral mucosa, palms, soles of the feet, and sometimes the buttocks, lasting for 7 to 10 days. The importance of CVA6 is its associated increased disease severity and systemic involvement.[5] Eczema coxsackium (EC) represents a self-limiting vesiculopapular eruption that occurs predominantly in children, caused by an enterovirus (usually CVA6), and affects areas of active or inactive atopic dermatitis. The coxsackieviruses are members of the I Picornaviridae i family which comprises non-enveloped single-stranded RNA viruses and includes notable members such as the enteroviruses, poliovirus, rhinovirus, and hepatitis A virus. [Extracted from the article]