A serum-free, purified vero cell rabies vaccine is safe and as immunogenic as the reference vaccine Verorab™ for pre-exposure use in healthy adults: Results from a randomized controlled phase-II trial.
- Resource Type
- Article
- Authors
- Pichon, Sylvie; Guinet-Morlot, Françoise; Minutello, Maria; Donazzolo, Yves; Rouzier, Regine; Chassard, Didier; Fitoussi, Serge; Hou, Victor
- Source
- Vaccine. Apr2013, Vol. 31 Issue 18, p2295-2301. 7p.
- Subject
- *RABIES vaccines
*VACCINE safety
*VIRAL vaccines
*IMMUNOLOGICAL tolerance
*IMMUNE response
*VACCINE biotechnology
*VACCINE research
*RANDOMIZED controlled trials
- Language
- ISSN
- 0264-410X
Highlights: [•] An improved generation purified Vero rabies vaccine (PVRV-NG) has been developed. [•] A randomized non-inferiority, phase II clinical trial was performed with a reference vaccine. [•] PVRV-NG was at least as immunologic as the reference rabies vaccine. [•] The results demonstrate that the PVRV-NG was well tolerated. [•] PVRV-NG can be safely given as a booster irrespective of primary series vaccine administered. [ABSTRACT FROM AUTHOR]