Parkinsonism Associated with Pathological 123I-FP-CIT SPECT (DaTSCAN) Results as the Initial Manifestation of Sporadic Creutzfeldt-Jakob Disease.
- Resource Type
- Case Study
- Authors
- Carrasco García de León, Sira; Cabello, Juan Pablo; Ortiz, Ramón; Vaamonde, Julia
- Source
- Case Reports in Neurological Medicine. 5/31/2018, p1-3. 3p.
- Subject
- *PARKINSONIAN disorders
*DOPAMINERGIC mechanisms
*MAGNETIC resonance imaging of the brain
*CAUDATE nucleus
- Language
- ISSN
- 2090-6668
Sporadic Creutzfeldt-Jakob disease (sCJD) is a type of progressive, subacute encephalopathy associated with spongiform degeneration of the central nervous system. sCJD includes a broad and heterogeneous spectrum of clinical variants, but extrapyramidal symptoms and signs at disease onset were rarely reported. We describe a case of unilateral parkinsonism associated with pathological 123I-ioflupane SPECT (DaTSCAN) results as the initial manifestation of M129V subtype sCJD patient. To the best of our knowledge, only 2 cases of Creutzfeldt-Jakob disease demonstrating nigrostriatal dopaminergic deficits in vivo using DaTSCAN have been published in the literature. [ABSTRACT FROM AUTHOR]