One‐Pot Preparation of Functionalized Azabicyclo[6.3.0]alkanone Amino Acids by Tandem Cross Enyne Metathesis/Ring‐Closing Metathesis.
- Resource Type
- Article
- Authors
- Bernardi, Eric; Colombo, Lino; De Lorenzi, Ersilia; Carraro, Massimo; Serra, Massimo
- Source
- European Journal of Organic Chemistry. 6/30/2020, Vol. 2020 Issue 24, p3568-3575. 8p.
- Subject
- *AMINO acids
*AMINO acid derivatives
- Language
- ISSN
- 1434-193X
Here we report an efficient one‐pot procedure for the preparation of functionalized azabicyclo[6.3.0]alkanone amino acid derivatives. The synthetic protocol exploits an ethylene‐mediated cross enyne metathesis followed by a ring closing metathesis. The reactivity of the newly synthesized 8,5‐fused bicyclic scaffolds has then been investigated to obtain variously functionalized derivatives with potential applications in the field of peptides/peptidomimetics. [ABSTRACT FROM AUTHOR]