The occurrence of antibodies against single-stranded DNA in the sera of patients with acute and chronic leukaemia.
- Resource Type
- Article
- Authors
- Izui, S.; Lambert, P. H.; Carpentier, N.; Miecher, P.A.
- Source
- Clinical & Experimental Immunology. Jun1976, Vol. 24 Issue 3, p379-384. 6p.
- Subject
- *ACUTE myeloid leukemia
*IMMUNOGLOBULINS
*DNA
*MYELOID leukemia
*GLOBULINS
*BLOOD plasma
- Language
- ISSN
- 0009-9104
One hundred and seventy-five sera from thirty-three patients with acute myeloid leukaemia, forty-two patients with chronic myeloid leukaemia and twelve patients with acute lymphatic leukaemia were examined by a radioimmunological technique for the presence of antibodies against single-stranded and double-stranded DNA. The levels of single-stranded DNA binding activity was significantly higher in all three types of leukaemia compared to those of healthy controls. In contrast, none of these sera exhibited a positive reaction with double-stranded DNA. In some cases the level of serum anti-DNA antibodies increased after the decrease of the leucocyte count. The presence of anti-DNA antibodies in leukaemic patients may have some biological significance. [ABSTRACT FROM AUTHOR]