I Objective: i To describe the adaptation of a hotel by a hospital-at-home team to provide hospital-level care to patients with COVID-19 during the first wave of the pandemic in Barcelona, Spain. I Background: i Since the first wave of COVID-19, alternatives to conventional hospitalization have been proposed for the provision of different levels of care, ranging from shelter during quarantine to hospital-level medical care ([1], [2]). According to HCB protocol, every frontline health care worker caring for patients with COVID-19 was screened weekly for SARS-CoV-2 infection by polymerase chain reaction testing ([4]). [Extracted from the article]