Postoperative pancreatic fistula (POPF) represents the most common and feared complication in pancreatic surgery because it can lead to other complications, some of which can be lethal. Kanda et al. analyzed 153 patients undergoing proximal and distal pancreatectomy complicated by POPF and showed that the elevation of the CRP level, >=28.4 mg/L, from POD1 to POD3, was an independent diagnostic factor for clinically relevant POPFs. Although the mortality at 90 days has declined, pancreaticoduodenectomy (PD) is an extremely complex surgical procedure, with a non-negligible rate of major postoperative complications [[1]]. This complication, as defined by the International Study Group for Pancreatic Fistulas (ISGPF), is divided into two main groups: clinically irrelevant fistulas (e.g., biochemical leaks) and clinically relevant pancreatic fistulas (CR-POPFs) requiring postoperative management adaptations (i.e., grades B and C). [Extracted from the article]