Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism.
- Resource Type
- Article
- Authors
- Häusl, Alexander S.; Bajaj, Thomas; Brix, Lea M.; Pöhlmann, Max L.; Hafner, Kathrin; De Angelis, Meri; Nagler, Joachim; Dethloff, Frederik; Balsevich, Georgia; Schramm, Karl-Werner; Giavalisco, Patrick; Chen, Alon; Schmidt, Mathias V.; Gassen, Nils C.
- Source
- Science Advances. 3/11/2022, Vol. 8 Issue 10, p1-16. 16p.
- Subject
- *MOLECULAR switches
*AUTOPHAGY
*POLYAMINES
*ORNITHINE decarboxylase
*METABOLISM
*ACETYLCOENZYME A
*LEUCINE
*PANCREATIC beta cells
- Language
- ISSN
- 2375-2548
The article presents a study which explores how mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism. It mentions that study provides an important novel regulatory function of MBH FKBP51 within the stress-adapted autophagy response to metabolic challenges.