Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts.
- Resource Type
- Article
- Authors
- Kamalov, M.; Harris, P. W. R.; Cooper, G. J. S.; Brimble, M. A.
- Source
- Chemical Communications. 2014, Vol. 50 Issue 38, p4944-4946. 3p.
- Subject
- *PROTEIN crosslinking
*ADVANCED glycation end-products
*PEPTIDES
*PROTEOLYSIS
*DICHROISM
- Language
- ISSN
- 1359-7345
Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism. [ABSTRACT FROM AUTHOR]