Discoid drug-induced lupus erythematosus induced by antitumor necrosis factor agents is a very rare subtype of cutaneous lupus: Three cases and literature review Drug-induced lupus erythematosus (DILE) is a lupus-like autoimmune disorder, which usually occurs with chronic exposure to certain drugs and resolves after cessation of the culprit medication.[1] The spectrum of DILE constantly evolves with that of the pharmacopeia.[1] In a recent study of 12 166 DILE identified from the WHO pharmacovigilance database, 118 drugs were identified.[2] This study showed that since 2007, antitumor necrosis factor (anti-TNF) agents have been the drugs most commonly associated with systemic DILE.[2] Such as idiopathic lupus, DILE can be classified in systemic and cutaneous DILE. The refractory features could raise the hypothesis of a classical systemic lupus erythematosus occurring under anti-TNF rather than a DILE. [Extracted from the article]