Bullous SLE: response to methotrexate and relationship with disease activity.
- Resource Type
- Article
- Authors
- Malcangi, G; Brandozzi, G; Giangiacomi, M; Zampetti, M; Danieli, MG
- Source
- Lupus. 2003, Vol. 12 Issue 1, p63-66. 4p.
- Subject
- *SYSTEMIC lupus erythematosus
*SKIN diseases
- Language
- ISSN
- 0961-2033
We report on a case of 40-year-old female with systemic lupus erythematosus (SLE) who developed a severe bullous eruption on sun-exposed areas. The bullous manifestation was associated with a flare of lupus serologies, whereas the previous manifestations of the disease were quiescent. Due to prior intolerance to many drugs, she was given oral methotrexate (10mg/week). The drug administration was followed by a rapid and full resolution of cutaneous lesions. Five months later she developed a class III lupus nephritis. Our case is the first report of efficacy of methotrexate in bullous SLE and rises the question of the relationship between bullous eruption and SLE activity. [ABSTRACT FROM AUTHOR]