Plasma soluble urokinase plasminogen activator receptor (suPAR) levels in systemic lupus erythematosus.
- Resource Type
- Article
- Authors
- Toldi, Gergely; Szalay, Balázs; Bekő, Gabriella; Bocskai, Márta; Deák, Magdolna; Kovács, László; Vásárhelyi, Barna; Balog, Attila
- Source
- Biomarkers. Dec2012, Vol. 17 Issue 8, p758-763. 6p.
- Subject
- *BLOOD plasma
*BLOOD
*UROKINASE
*PLASMINOGEN activators
*SYSTEMIC lupus erythematosus
- Language
- ISSN
- 1354-750X
Objective: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of systemic inflammation. We aimed to characterize plasma suPAR levels in SLE patients. Methods: We measured plasma suPAR, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in 89 SLE patients and 29 healthy controls. Results: suPAR and ESR values were higher in SLE than in controls, while CRP levels were comparable. ROC analysis of suPAR levels indicated a cut-off value of 5.70 ng/mL to distinguish patients with high disease activity (SLEDAI >8). Conclusion: suPAR might be an objective marker for identifying SLE patients with active disease. [ABSTRACT FROM AUTHOR]