Objective: Due to variable cranial morphologies, ventricular access in patients with craniosynostosis using conventional techniques is often challenging. Whilst ventricular access may not be frequently required in scaphocephalic patients, it is vital that an ideal location of the access points is established for safe ventricular catheterization. This study aimed to document the morphometry of commonly used ventricular access points, i.e. Kocher's and Frazier's points, within a select South African scaphocephalic pediatric population. Methods: The craniometric dimensions of Kocher's and Frazier's points were measured relative to anatomical and craniometric landmarks on pre-operative computed tomography scans of 24 consecutive patients diagnosed with scaphocephaly between 2014 and 2020. The results were compared against age, sex, population group and the degree of severity [Ethical approval number: BREC/00002084/2020]. Results: Kocher's point was located between 91.6 mm and 140 mm posterior to the nasion, and between 20.5 mm and 34.6 mm lateral to the midline. Statistically significant increases were reported in the mean distance posterior to nasion between patients in the <1 year and older age groups (>1-<9 years) (ANOVA, p<0.001); and in the mean distance lateral to the midline (ANOVA, p=0.004), between patients in the <1 year and 3- <6-year (post-hoc, p=0.002) and 1-<3-year and 3-<6-year (posthoc, p=0.030) age groups, respectively. Frazier's point was located between 60.9 mm and 82.8 mm superior to the inion, and 25.9 mm and 41.4 mm lateral to the midline. Conclusion: Traditional landmarks used for ventricular access can be unreliable in scaphocephalic patients. This study provides novel morphometric data for neurosurgical consideration regarding ventricular catheterization procedures in scaphocephalic patients. [ABSTRACT FROM AUTHOR]