New Methodology for the Synthesis of α,α-difluoroketones.
- Resource Type
- Article
- Authors
- Biju, Purakkattle
- Source
- Synthetic Communications. 2008, Vol. 38 Issue 12, p1940-1945. 6p. 2 Diagrams, 1 Chart.
- Subject
- *AMIDES
*CHEMICAL processes
*ORGANOLITHIUM compounds
*KETONES
*CHEMICAL reagents
- Language
- ISSN
- 0039-7911
A new methodology is described for the synthesis of α,α-difluorinated ketones by the addition of organolithium reagents to α,α-difluoro-N-methoxy-N-methyl amides (Weinreb amides). [ABSTRACT FROM AUTHOR]