Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.
- Resource Type
- Letter
- Authors
- Sahm, Felix; Toprak, Umut; Hübschmann, Daniel; Kleinheinz, Kortine; Buchhalter, Ivo; Sill, Martin; Stichel, Damian; Schick, Matthias; Bewerunge-Hudler, Melanie; Schrimpf, Daniel; Zadeh, Gelareh; Aldape, Ken; Herold-Mende, Christel; Beck, Katja; Staszewski, Ori; Prinz, Marco; Harosh, Carmit; Eils, Roland; Sturm, Dominik; Jones, David
- Source
- Acta Neuropathologica. Jul2017, Vol. 134 Issue 1, p155-158. 4p.
- Subject
- *MENINGIOMA
*PHYSIOLOGICAL effects of radiation
*SINGLE nucleotide polymorphisms
*GENETICS
- Language
- ISSN
- 0001-6322
The article offers information on genome sequencing of meningioma induced by low-dose radiation and mentions presence of single nucleotide variations of Neurofibromatosis 2; methylation data; and consequence of genomic rearrangements caused by irradiation.