Congenital factor VII (FVII) deficiency is the most common of the rare bleeding disorders with an estimated prevalence of 1:500,000 cases. [1] An isolated acquired FVII deficiency is even less frequent, although acquired FVII deficiency, along with FII, FV, and FX deficiencies, may be commonly identified in situations of vitamin K deficiency (liver disease, malabsorption, anticoagulant therapy with vitamin K antagonists). [2][3] An isolated acquired FVII deficiency may be suspected in individuals with a prolongation of prothrombin time (PT), a normal activated partial thromboplastin time (aPTT) and a personal and family history negative for inherited bleeding disorders. [Extracted from the article]