Synthesis of Cardiac Glycoside Analogs by Catalyst-Controlled, Regioselective Glycosylation of Digitoxin.
- Resource Type
- Article
- Authors
- Beale, Thomas M.; Taylor, Mark S.
- Source
- Organic Letters. Mar2012, Vol. 14 Issue 6, p1358-1361. 4p.
- Subject
- Language
- ISSN
- 1523-7060
The cardiac glycoside natural product digitoxin was selectively glycosylated at one of its five hydroxyl groups using a borinic acid derived catalyst. This method provided access to the glycosylation pattern characteristic of a subclass of natural products from Digitalis purpurea. Variation of the glycosyl donor was tolerated, enabling the synthesis of novel cardiac glycoside analogs from readily available materials. [ABSTRACT FROM AUTHOR]