Beast of (renal) burden? Bst1-expressing neutrophils in kidney injury.
- Resource Type
- Article
- Authors
- Collett, Jason A.; Basile, David P.
- Source
- American Journal of Physiology: Renal Physiology. Feb2024, Vol. 326 Issue 2, pF165-F166. 2p.
- Subject
- *NEUTROPHILS
*LIPOCALINS
*KIDNEY injuries
*MESENCHYMAL stem cells
- Language
- ISSN
- 1931-857X
The article titled "Beast of (renal) burden? Bst1-expressing neutrophils in kidney injury" discusses the role of neutrophils in acute kidney injury (AKI) and the potential therapeutic target of bone marrow stromal cell antigen-1 (Bst1/CD157) in mediating the immune response following AKI. The study found that Bst1-deficient mice exhibited a significant attenuation of AKI compared to wild-type mice, suggesting that Bst1 expression in hematopoietic stem cells, particularly neutrophils, plays a crucial role in inducing AKI. The authors also highlighted the need for further research to understand the cellular and molecular mechanisms of the innate immune system in kidney ischemia. [Extracted from the article]