Background: Schizophrenia is a severe mental disorder. For normal metabolism, trace elements are essential. It is suggested that trace elements alterations are associated with schizophrenia.Aims and objectives:This study was conducted to evaluate the association between schizophrenia risk and serum levels of copper and zinc. Materials and Methods:The study was conducted in the Department of Biochemistry laboratory of SRG Hospital, Jhalawar Medical College, Jhalawar (Rajasthan). The present study comprised of 100 subjects among them 50 normal healthy controls without any clinical symptoms or disease and 50 Schizophrenia diseases. The statistical analysis was performed by using in SPSS version 12.0 and Microsoft excels 2007. Results:There was a statistically significant increase in serum copper level in schizophrenia subjects (cases) as compared to healthy control groups (p<0.0001). The percentage of low, high, normal and overall distribution of copper in schizophrenia subjects (cases) were L= 0.0%, H= 94.0%, N= 6.0% and T= 100% respectively and the percentage of low, high, normal, and overall, in healthy (control) groups were L= 2.0%, H= 10.0%, N= 88.0% and T= 100% respectively and total percentage respectively L= 1.0%, H= 52.0%, N= 47.0% and T= 100.0%, which indicates high significance in schizophrenia subjects and low in healthy control groups. We have also found that there was a statistically significant decrease in zinc level in schizophrenia subjects (cases) as compared to healthy control groups (p<0.0001). Conclusion:In our study, we observed that brain function was altered in schizophrenia disease patients that subsequently lead to trace element dysfunction and we concluded that monitoring of trace elements may be beneficial to Schizophrenia patients. [ABSTRACT FROM AUTHOR]