NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
- Resource Type
- Article
- Authors
- Radulovic, Katarina; Ayata, C. Korcan; Mak'Anyengo, Rachel; Lechner, Kristina; Wuggenig, Philipp; Kaya, Berna; Hruz, Petr; des Gomez de Agüero, Merce; Broz, Petr; Weigmann, Benno; Niess, Jan Hendrik
- Source
- Journal of Immunology. 7/15/2019, Vol. 203 Issue 2, p544-556. 13p.
- Subject
- *T cells
*CELL death
*PATTERN perception receptors
*IMMUNOREGULATION
*EPITHELIAL cells
- Language
- ISSN
- 0022-1767
The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4+ T cells led to decreased survival. [ABSTRACT FROM AUTHOR]